In Dice Hospital: ER – Emergency Roll everyone attempts to treat as many patients in their hospital as possible, filling their wards, admitting extra or critical patients, choosing when and where to station nurses and using screens to isolate patients, and satisfying the demands of the three Specialists.

Every round the active player flips over an ambulance card revealing three actions, and are tied to the dice which are also rolled and allocated underneath their respective colours on the card. Once the active player picks their action, other players choose any non-selected action and associated die to do their own action. At the end of the round the player sitting to the left of the active player, becomes the new active player.

The game is over when the Ambulance deck is used up. The player with the most points wins the game.

Dice Hospital: ER – Emergency Roll is a standalone 'flip, roll and write' game in the Dice Hospital universe.